Principal Investigator (PI)
The Foundation is providing £132,140 in support.
Dr Alexios Matralis - Adnan Malik
Starting from a set of compounds prepared by D. Baker’s group that showed activity in GSK phenotypic and dual gamete formation assays on top of its activity against P. falciparum cGMP-dependent protein kinase (PfPKG), this open lab will focus on improve the physchem profile of these families, increase their potency in the phenotypic/dual gamete formation assays, abolish toxicity issues, and gain knowledge of their in vitro killing profile in order to focus only in fast killing compounds. The aim of the project is to deliver compounds active in vivo in the P. falciparum mouse model, with physicochemical properties that allow developability and adequate safety profile.