Open Labs Fellow/s

Ana Sánchez Azqueta

GSK’s contribution

GSK provides in-kind contributions, including expertise, facilities and consumables to develop and perform the HTS, access to compound collection (TCAMS), early in vitro toxicology and in vitro ADME studies as well as drug discovery expertise for hit prioritisation once the HTS campaign has been completed.

Project Description

This project will address whether protein kinase inhibitors specific against the PfCLK kinases can be developed as a safe and curative treatment for malaria. Furthermore, this project will also contribute to the question of whether protein kinase inhibitors can be used to target malaria beyond the blood stage. This project will specifically address the following problems:
- To define selective inhibitors to the PfCLK family
- To determine the anti-malarial activity of PfCLK the inhibitors (in vitro and in vivo) and establish the mode of action of the inhibitors
The duration of the project is expected to be 12 months and will involve a close collaboration between the MRC’s Toxicology Unit and scientists at GSK’s Tres Cantos Medicines Development Campus.

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