The Tres Cantos Open Lab Foundation announced today the funding of a one-year project with the University of Liverpool to work on new triazole derivatives. These molecules were discovered by GSK and made available to the scientific community along with 13,500 other hits. The group from Liverpool will optimize this chemical class based on early hit profiling and results from the pharmacological assays. These compounds may target serine proteases and if a validated lead is reached during the first year, support for a second year will be aimed at mode of action identification.
The funds provided by the Tres Cantos Open Lab Foundation will support a visiting researcher to come to GSK’s R&D centre in Tres Cantos (Spain) to pursue their project as part of an integrated drug discovery team. Medicinal chemistry and drug discovery expertise at GSK will be paramount for the progress of this project.
“This project is a good example of a collaborative effort to bring new treatments against malaria through exploitation of the Tres Cantos anti-malarial set” said Dr Paul O’Neill, professor of chemistry at the University of Liverpool.
“There is a need for new and better anti-malarial agents. The combination of knowledge and expertise from the University of Liverpool and Tres Cantos is a good base for success of this project.” said Professor Sir Leszek Borysiewicz, Trustee and Chair of the Governing Board, Tres Cantos Open Lab Foundation (currently Vice-Chancellor of the University of Cambridge, previously Chief Executive of the Medical Research Council).
About the Tres Cantos Open Lab Foundation
The Tres Cantos Open Lab Foundation is focused on providing funding and support for scientists, academics and institutions to develop and advance new ideas that could lead to new medicines to treat diseases of the developing world. Researchers are invited to submit projects for collaboration and funding, to be reviewed by the Foundation’s Governing Board and Trustees.
About the University of Liverpool
The University of Liverpool is one of the UK’s leading research institutions with an annual turnover of £410 million, including £150 million for research. Liverpool is ranked in the top 1% of higher education institutions worldwide and is a member of the Russell Group.