Dr R. Kip Guy is currently the Dean of Pharmacy and a Professor of Pharmaceutical Sciences at the University of Kentucky in Lexington, Kentucky, USA.
Dr Guy obtained his BA in chemistry from Reed College in Portland, OR in 1990. After college, he worked as a process development chemist in the Process Translation Unit at IBM-Almaden in San Jose, CA. In 1996, he received his PhD in Organic Chemistry based on the total synthesis of taxol from the Scripps Research Institute (TSRI) La Jolla, CA. While at Scripps he held an Office of Naval Research Graduate Research Fellowship, George Hewitt Medical Research Fellowship, and ACS Organic Division Fellowship. He also carried out additional training in Physiology at the Woods Hole Research Institute in Woods Hole, MA in 1995. From 1996 to 1998, he was a Helen Hay Whitney Postdoctoral Fellow in Cellular Biology focusing on the relationship between hedgehog signaling and sterol homeostasis with Drs. Brown and Goldstein at University of Texas Southwestern Medical Center, Dallas, TX. From 1998 to 2005 he held a joint appointment in the Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology at the University of California, San Francisco (Assistant to Full Professor, currently Adjunct Professor). From 2005 to 2016 he was the founding Chair of the Department of Chemical Biology and Therapeutics at St Jude Children’s Research Hospital where he also held Adjunct appointments at the University of Tennessee and Vanderbilt University. He has been at UK since 2016
His research is focused on the discovery and development of novel small molecules that target the pathophysiology of orphan paediatric diseases, particularly paediatric oncology and protozoal infectious diseases. Most of his group’s work falls into the areas of chemical validation of novel targets, lead discovery and optimization of novel chemical matter for validated disease targets, and use of non-targeted whole-cell strategies for lead discovery and optimization. He is the author of 160 papers and book chapters, and the inventor on 14 issued patents.